The drug offers some benefits for patients with lymphomas of other than hodgkins type and small and large cell carcinomas of lung, but there has been no documented enlargement of the role of procarbazine beyond these applications during the past 5 years. Procarbazine may cause fetal harm if administered to a pregnant female. Ibenzmethyzin in the management of late hodgkins disease, in report of the proceedings of a symposium, downing college, cambridge, june 22, 1965. Matulane patient assistance program patient assistance programs. Oncometabolite d2hydroxyglutarate inhibits alkbh dna repair. Apr 10, 2018 procarbazine can be taken with or without food, but at the same time each day. Thirtyeight patients with advanced hodgkins disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone cvpp. In addition, other persons living in your household should not take or should not have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Longterm survival of patients with hodgkins disease. Article pdf available in european journal of cancer 40. If you submit this form, please be aware that your name and email may be provided to third parties. A demonstration of the in vitro bacterial mutagenicity of. Oncometabolite d2hydroxyglutarate inhibits alkbh dna repair enzymes and.
Twentyeight patients 74% achieved complete remission. Vincristine 14 mgm 2 suggested dose capping at 28 mg was given on days 1 and 15. Procarbazine hydrochloride pcz, a chemotherapeutic agent used extensively to treat hodgkins disease and other tumors,induces leukemia, lymphoma, ma we use cookies to enhance your experience on our website. In vitro activation of procarbazine to sytotoxic species. Dec 10, 2014 procarbazine quickly equilibrates between the blood and cerebrospinal fluid csf. The anticancer activity of this agent results from oxidation to azoprocarbazine and additional noxidation to a mixture of azoxy isomers. Patients in the methotrexate, procarbazine, vincristine, and cytarabine group received three 28day cycles of chemotherapy. Procarbazine and procarbazine hydrochloride are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. Procarbazine 100 mgm 2 per day was given on days 17. This file contains additional information such as exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. Find patient medical information for procarbazine oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Procarbazine is a chemotherapy medication used for the treatment of hodgkins lymphoma and brain cancers. Patient information include the front and back copy of the patients insurance card. It works by slowing or stopping the growth of cancer cells in your body.
Interactions between procarbazine oral and avoidhigh. Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with hodgkins disease. Procarbazine is given with other cancer medicines to treat hodgkins disease a type of. Nov 09, 2018 procarbazine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Patient information include the front and back copy of. The following doses are for administration of the drug as a single agent. Aug 20, 2003 procarbazine in treating patients with recurrent brain tumor the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. Procarbazine should therefore be used only against malignant disease by clinicians experienced in its use and cognizant of potential adverse effects. Procarbazine in the management of late hodgkins disease. By continuing to use our website, you are agreeing to our use of cookies.
This article is from mediterranean journal of hematology and infectious diseases, volume 4. Oncometabolite d2hydroxyglutarate inhibits alkbh dna. For hodgkins it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and. Phase i trial of procarbazine as a 5day continuous. Procarbazine is an orally administered alkylating agent used in combination with other antineoplastic agents in the therapy of hodgkins disease and malignant melanoma. Methotrexate 35 gm 2 was given on an identical dosing schedule days 1 and 15 as described above. It also inhibits mao thus increasing the effects of sympathomimetics, tcas, and tyramine. The names procarbazine and procarbazine hydrochloride are used interchangeably in published studies.
Pdf procarbazine, lomustine and vincristine pcv in. Matulane patient assistance program patient assistance. Procarbazine side effects, dosage, interactions drugs. Procarbazine and lomustine in recurrent glioblastoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Enter synonyms, trade names or additional information found in section 1. Procarbazine and lomustine in recurrent glioblastoma. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the transmethylation of methionine into transfer rna trna, thereby preventing protein synthesis and consequently dna and rna synthesis. In addition, other persons living in your household should not take or should not have recently taken oral polio vaccine since there is. The metabolism of procarbazine was studied using spintrapping techniques. File scanned at 300 ppi monochrome, 24bit color using scandall pro 1. Procarbazine and lomustine in recurrent glioblastoma full. Peak csf levels are achieved 3090 minutes after oral administration.
Procarbazine in treating patients with recurrent brain tumor. Procarbazine from wikipedia, the free encyclopedia jump to navigation jump to search. Procarbazine in treating patients with recurrent brain tumor the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Furthermore, the differential mutagenic effects obtained using s. Surfduedlqh cancer care ontario cancer care ontario. Procarbazine therapy has been associated with serum enzyme elevations during therapy and with rare cases of idiosyncratic, clinically apparent acute liver injury. Procarbazine is rapidly metabolised, the primary circulating metabolite is the azo derivative while the major urinary metabolite has been shown to be nisopropyl. For hodgkins it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. This compound has consistently yielded false negative results in in vitro microbial mutagenicity tests in the presence and absence of mammalian metabolic activation. Cancer studies in experimental animals exposure to procarbazine hydrochloride by intraperitoneal injec. Procarbazine side effects, dosage, interactions drugs everyday health search. Procarbazine is usually administered concomitantly with other appropriate cytostatic drugs in repeated four to sixweekly cycles.
Combination chemotherapy with four drugsnitrogen mustard, vincristine, procarbazine and prednisonewas used in 27 previously treated patients with advanced progressive hodgkins disease. These isomers were synthesized and purified, and their cytotoxic effects against leukemia. Procarbazine is used in combination with other medications to treat certain types of hodgkins disease types of cancer that begin in a type of white blood cells that normally fights infection. Combination chemotherapy with nitrogen mustard, vincristine. Webmd provides information about interactions between procarbazine oral and avoidhightyraminefoods. Procarbazine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Matulane is used as part of the mopp nitrogen mustard, vincristine, procarbazine, prednisone regimen. Phase i trial of procarbazine as a 5day continuous infusion. This file is licensed under the creative commons attributionshare alike 4. However, some foods may interact with procarbazine. Procarbazine is in a class of medications called alkylating agents. Procarbazine carcinogenicity in methotrexatetreated or. Intracellular oxidation of glutathione in l5178y lymphoma cells by procarbazine and diamide. Nov 29, 2012 procarbazine and lomustine in recurrent glioblastoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Myelosuppression was moderate though occasionally delayed, and nausea and vomiting were mild. Procarbazine can be taken with or without food, but at the same time each day. Procarbazine is an antineoplastic chemotherapy drug for the treatment of hodgkins lymphoma and certain brain cancers such as glioblastoma multiforme. The drug is metabolized and activated in the liver. Oct 04, 2018 matulane is indicated for use in combination with other anticancer drugs for the treatment of stage iii and iv hodgkins disease. Each capsule also contains cornstarch, mannitol and talc. Ris zotero endnote bibtex medlars procite refworks reference manager mendeley. Reappraisal of the use of procarbazine in the treatment of.
Seven children with previously treated brain tumors were enrolled in a phase i trial of 5day continuousinfusion procarbazine at 360, 480, and 638 mgm2day. This page was last edited on 8 january 2016, at 21. It has been used in the treatment of many cancers, but its main use is in the treatment of hodgkins lymphoma and brain tumors and, to a lesser extent, nonhodgkins lymphoma and primary central nervous system lymphoma. Files are available under licenses specified on their description page. All structured data from the file and property namespaces is available under the creative commons cc0 license. Oncometabolite d2hydroxyglutarate inhibits alkbh dna repair enzymes and sensitizes idh mutant cells to alkylating agents. Procarbazine may also be used for purposes not listed in this medication guide. Pdf available procarbazine, lomustine and vincristine pcv in recurrent glioblastoma gbm retrospective single institution study evaluating survival and response rates november 2014. Pdf link pdf citation stanley lowenbraun, vincent t. Procarbazine hcl is a nonclassical oral alkylating anticancer agent that was first synthesized in the late 1950s. S0182 hcpcs code procarbazine, oral hcpcs registry.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. As of 20, this field contains the consumer friendly descriptions for the ama cpt codes. Matulane procarbazine hydrochloride, a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride. Abstractpatients with hodgkin lymphoma treated with dnabreaking. Before using procarbazine, report the use of drugs that may increase the risk of extremely high blood pressure hypertensive crisis when combined with procarbazine, including herbal products. Ibenzmethyzin in the management of late hodgkins disease, in report of the proceedings of a symposium.
Amethopterin, amethopterine, antifolin, methotrexat, methylaminopterin, methylaminopterium, ledertrexate. There are case reports of fetal malformations in the offspring of pregnant women exposed to procarbazine as part of a combination chemotherapy regimen. Procarbazine, lomustine and vincristine pcv in recurrent glioblastoma gbm retrospective single institution study evaluating survival and response rates november 2014 doi. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Procarbazine is a methylhydrazine derivative with antineoplastic and mutagenic activities. Methylprednisolone was given on days 15 and filgrastim 5. Along with their needed effects, medicines like procarbazine can sometimes cause unwanted effects such as blood problems, loss of hair, high blood pressure reactions, and other side effects. Procarbazine should be taken whole and not crushed, cut, or dissolved. Pdf procarbazine pcb was developed in the 1960s and was rapidly recognised as an active agent in lymphoid malignancies. If you are unable to swallow procarbazine, talk to. Tmic is funded by genome alberta, genome british columbia, and genome canada, a notforprofit. Listing a study does not mean it has been evaluated by the u.
The oxidation of procarbazine, catalyzed by horseradish peroxidase, prostaglandin synthetase ram seminal vesicle rsv microsomes or rat hepatic microsomal. Procarbazine may lower your bodys resistance and there is a chance you might get the infection the immunization is meant to prevent. Oehha is subject to the california public records act and other laws that require the release of certain information upon request. Page 1 procarbazine oral chemotherapy education name of your medication generic name procarbazine proh kar buh zeen brand name matulane ma choo layn approved uses procarbazine is used to treat hodgkins disease. It is a member of a group of medicines called alkylating agents. The antineoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential. Procarbazine is given with other cancer medicines to treat hodgkins disease a type of blood cancer. In most such combination chemotherapy regimens currently in use eg. Procarbazine is a 1,2disubstituted hydrazine derivative that acts as a methylating agent in the treatment of hodgkins disease, leukemias, lymphomas, and brain tumors. Please see the drug and food interactions section for more details. Evidence for carboncentered freeradical intermediates. Intracellular oxidation of glutathione in l5178y lymphoma.
569 848 471 1480 739 125 1629 1541 1512 1632 1610 981 894 136 82 664 776 6 1081 246 326 941 1231 394 91 1089 1099 1386 1328 1409 965 211